Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas

M. Udugama; L. Hii; A. Garvie; M. Cervini; B. Vinod; F.-L. Chan; P. P. Das; J. R. Mann; P. Collas; H. P. J. Voon; L. H. Wong

doi:10.1038/s41467-021-22543-z

Nature Communications (May 2021)

Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas

M. Udugama,
L. Hii,
A. Garvie,
M. Cervini,
B. Vinod,
F.-L. Chan,
P. P. Das,
J. R. Mann,
P. Collas,
H. P. J. Voon,
L. H. Wong

Affiliations

M. Udugama: Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
L. Hii: Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
A. Garvie: Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
M. Cervini: Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
B. Vinod: Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
F.-L. Chan: Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
P. P. Das: Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University
J. R. Mann: Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University
P. Collas: Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo
H. P. J. Voon: Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
L. H. Wong: Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University

DOI: https://doi.org/10.1038/s41467-021-22543-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

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Alternative Lengthening of Telomeres (ALT) is a telomere maintenance pathway utilised in 15% of cancers that have been associated with mutations in ATRX. Here the authors reveal a functional role of histone demethylases KDM4B in regulating ALT activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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