In this study, a new oscillation criterion for the fourth-order neutral delay differential equation ruxu+puxδu‴α′+quxβϕu=0,u≥u0 is established. By introducing a Riccati substitution, we obtain a new criterion for oscillation without requiring the existence of the unknown function. Furthermore, the new criterion improves and complements the previous results in the literature. The results obtained are illustrated by an example.