Journal of Clinical Medicine (Mar 2023)
Cardiovascular Side Effects of Anthracyclines and HER2 Inhibitors among Patients with Breast Cancer: A Multidisciplinary Stepwise Approach for Prevention, Early Detection, and Treatment
- Ciro Mauro,
- Valentina Capone,
- Rosangela Cocchia,
- Filippo Cademartiri,
- Ferdinando Riccardi,
- Michele Arcopinto,
- Maie Alshahid,
- Kashif Anwar,
- Mariano Carafa,
- Andreina Carbone,
- Rossana Castaldo,
- Salvatore Chianese,
- Giulia Crisci,
- Roberta D’Assante,
- Mariarosaria De Luca,
- Monica Franzese,
- Domenico Galzerano,
- Vincenzo Maffei,
- Alberto M. Marra,
- Valeria Valente,
- Federica Giardino,
- Alfredo Mazza,
- Brigida Ranieri,
- Anna D’Agostino,
- Salvatore Rega,
- Luigia Romano,
- Sarah Scagliarini,
- Chiara Sepe,
- Olga Vriz,
- Raffaele Izzo,
- Antonio Cittadini,
- Eduardo Bossone,
- Andrea Salzano
Affiliations
- Ciro Mauro
- Cardiology Division, Antonio Cardarelli Hospital, Via Cardarelli 9, 80131 Naples, Italy
- Valentina Capone
- Cardiology Division, Antonio Cardarelli Hospital, Via Cardarelli 9, 80131 Naples, Italy
- Rosangela Cocchia
- Cardiology Division, Antonio Cardarelli Hospital, Via Cardarelli 9, 80131 Naples, Italy
- Filippo Cademartiri
- Department of Radiology, Fondazione G. Monasterio CNR-Regione Toscana, Via Moruzzi 1, 56124 Pisa, Italy
- Ferdinando Riccardi
- Oncology Unit, Antonio Cardarelli Hospital, Via Cardarelli 9, 80131 Naples, Italy
- Michele Arcopinto
- Department of Translational Medical Sciences, Federico II University, 80138 Naples, Italy
- Maie Alshahid
- The Heart Centre, King Faisal Specialist Hospital & Research Centre, Riyadh 11564, Saudi Arabia
- Kashif Anwar
- The Heart Centre, King Faisal Specialist Hospital & Research Centre, Riyadh 11564, Saudi Arabia
- Mariano Carafa
- Emergency Medicine Division, Antonio Cardarelli Hospital, Via Cardarelli 9, 80131 Naples, Italy
- Andreina Carbone
- Unit of Cardiology, Department of Translational Medical Sciences, Monaldi Hospital, University of Campania Luigi Vanvitelli, 80131 Naples, Italy
- Rossana Castaldo
- IRCCS SYNLAB SDN, Via Emanuele Gianturco 113, 80143 Naples, Italy
- Salvatore Chianese
- Cardiology Division, Antonio Cardarelli Hospital, Via Cardarelli 9, 80131 Naples, Italy
- Giulia Crisci
- Department of Translational Medical Sciences, Federico II University, 80138 Naples, Italy
- Roberta D’Assante
- Department of Translational Medical Sciences, Federico II University, 80138 Naples, Italy
- Mariarosaria De Luca
- Department of Translational Medical Sciences, Federico II University, 80138 Naples, Italy
- Monica Franzese
- IRCCS SYNLAB SDN, Via Emanuele Gianturco 113, 80143 Naples, Italy
- Domenico Galzerano
- The Heart Centre, King Faisal Specialist Hospital & Research Centre, Riyadh 11564, Saudi Arabia
- Vincenzo Maffei
- Post Operative Intensive Care Division, Antonio Cardarelli Hospital, 80131 Naples, Italy
- Alberto M. Marra
- Department of Translational Medical Sciences, Federico II University, 80138 Naples, Italy
- Valeria Valente
- Department of Translational Medical Sciences, Federico II University, 80138 Naples, Italy
- Federica Giardino
- Department of Translational Medical Sciences, Federico II University, 80138 Naples, Italy
- Alfredo Mazza
- Unit of Cardiology, Camerino Hospital, 62032 Macerata, Italy
- Brigida Ranieri
- IRCCS SYNLAB SDN, Via Emanuele Gianturco 113, 80143 Naples, Italy
- Anna D’Agostino
- IRCCS SYNLAB SDN, Via Emanuele Gianturco 113, 80143 Naples, Italy
- Salvatore Rega
- Department of Public Health, University Federico II of Naples, Via Sergio Pansini 5, 80131 Naples, Italy
- Luigia Romano
- Department of General and Emergency Radiology, Antonio Cardarelli Hospital, Via Cardarelli 9, 80131 Naples, Italy
- Sarah Scagliarini
- Oncology Unit, Antonio Cardarelli Hospital, Via Cardarelli 9, 80131 Naples, Italy
- Chiara Sepe
- Technical Nursing and Rehabilitation Service (SITR) Department, Cardarelli Hospital, 80131 Naples, Italy
- Olga Vriz
- The Heart Centre, King Faisal Specialist Hospital & Research Centre, Riyadh 11564, Saudi Arabia
- Raffaele Izzo
- Department of Advanced Biomedical Sciences, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, Italy
- Antonio Cittadini
- Department of Translational Medical Sciences, Federico II University, 80138 Naples, Italy
- Eduardo Bossone
- Department of Public Health, University Federico II of Naples, Via Sergio Pansini 5, 80131 Naples, Italy
- Andrea Salzano
- Cardiology Division, Antonio Cardarelli Hospital, Via Cardarelli 9, 80131 Naples, Italy
- DOI
- https://doi.org/10.3390/jcm12062121
- Journal volume & issue
-
Vol. 12,
no. 6
p. 2121
Abstract
Cardiovascular (CV) diseases (CVD) are a major cause of long-term morbidity and mortality affecting life expectancy amongst cancer survivors. In recent years, because of the possibility of early diagnosis and the increased efficacy of neo-adjuvant and adjuvant systemic treatments (targeting specific molecular pathways), the high percentage of survival from breast cancer led CVD to become the first cause of death among survivors. Therefore, it is mandatory to adopt cardioprotective strategies to minimize CV side effects and CVD in general in breast cancer patients. Cancer therapeutics-related cardiac dysfunction (CTRCD) is a common group of side effects of chemotherapeutics widely employed in breast cancer (e.g., anthracycline and human epidermal growth factor receptor 2 inhibitors). The aim of the present manuscript is to propose a pragmatic multidisciplinary stepwise approach for prevention, early detection, and treatment of cardiotoxicity in patients with breast cancer.
Keywords