CircAnks1a in the spinal cord regulates hypersensitivity in a rodent model of neuropathic pain

Su-Bo Zhang; Su-Yan Lin; Meng Liu; Cui-Cui Liu; Huan-Huan Ding; Yang Sun; Chao Ma; Rui-Xian Guo; You-You Lv; Shao-Ling Wu; Ting Xu; Wen-Jun Xin

doi:10.1038/s41467-019-12049-0

Nature Communications (Sep 2019)

CircAnks1a in the spinal cord regulates hypersensitivity in a rodent model of neuropathic pain

Su-Bo Zhang,
Su-Yan Lin,
Meng Liu,
Cui-Cui Liu,
Huan-Huan Ding,
Yang Sun,
Chao Ma,
Rui-Xian Guo,
You-You Lv,
Shao-Ling Wu,
Ting Xu,
Wen-Jun Xin

Affiliations

Su-Bo Zhang: Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Rehabilitation Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
Su-Yan Lin: Guangdong Province Key Laboratory of Brain Function and Disease, Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University
Meng Liu: Guangdong Province Key Laboratory of Brain Function and Disease, Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University
Cui-Cui Liu: Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Rehabilitation Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
Huan-Huan Ding: Guangdong Province Key Laboratory of Brain Function and Disease, Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University
Yang Sun: Department of Rehabilitation Medicine, the Second Affiliated Hospital of Xi’an Medical University
Chao Ma: Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Rehabilitation Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
Rui-Xian Guo: Guangdong Province Key Laboratory of Brain Function and Disease, Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University
You-You Lv: Neuroscience Program, Zhongshan School of Medicine, the Fifth Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University
Shao-Ling Wu: Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Rehabilitation Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
Ting Xu: Guangdong Province Key Laboratory of Brain Function and Disease, Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University
Wen-Jun Xin: Guangdong Province Key Laboratory of Brain Function and Disease, Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University

DOI: https://doi.org/10.1038/s41467-019-12049-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

Read online

Circular RNAs are non-coding RNAs that are enriched in the CNS, but their role in chronic pain is not known. Here the authors show that CircAnks1a in dorsal horn neurons contributes to pain-like hypersensitivity in a rodent model of neuropathic pain, via a VEGF mechanism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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