Beilstein Journal of Organic Chemistry (Sep 2022)

Lewis acid-catalyzed Pudovik reaction–phospha-Brook rearrangement sequence to access phosphoric esters

  • Jin Yang,
  • Dang-Wei Qian,
  • Shang-Dong Yang

DOI
https://doi.org/10.3762/bjoc.18.123
Journal volume & issue
Vol. 18, no. 1
pp. 1188 – 1194

Abstract

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Herein, we report a Lewis acid-catalyzed Pudovik reaction–phospha-Brook rearrangement sequence between diarylphosphonates or -phosphinates and α-pyridinealdehydes to access valuable phosphoric ester compounds. This transformation provides an extended substrate scope that is complementary to similar previously reported base-catalyzed transformations.

Keywords