Communications Biology (Nov 2021)

Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis

  • Dennis Ma,
  • Grace A. Hernandez,
  • Austin E. Y. T. Lefebvre,
  • Hamad Alshetaiwi,
  • Kerrigan Blake,
  • Kushal R. Dave,
  • Maha Rauf,
  • Justice W. Williams,
  • Ryan T. Davis,
  • Katrina T. Evans,
  • Aaron Longworth,
  • Madona Y. G. Masoud,
  • Regis Lee,
  • Robert A. Edwards,
  • Michelle A. Digman,
  • Kai Kessenbrock,
  • Devon A. Lawson

Journal volume & issue
Vol. 4, no. 1
pp. 1 – 15


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Ma, Hernandez et al develop a 3D culture-transplant system to enable studies of cancer metastasis using patient-derived xenograft (PDX) tumor cells. Using this system, they find that OXPHOS inhibition attenuates the lung metastatic capacity of breast cancer cells and that overexpression of the metabolic enzyme NME1 increases lung metastasis.