Pharmaceuticals (Mar 2010)

Synthetic Medicinal Chemistry in Chagas’ Disease: Compounds at The Final Stage of “Hit-To-Lead” Phase

  • Hugo Cerecetto,
  • Mercedes González

DOI
https://doi.org/10.3390/ph3040810
Journal volume & issue
Vol. 3, no. 4
pp. 810 – 838

Abstract

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Chagas’ disease, or American trypanosomosiasis, has been the most relevant illness produced by protozoa in Latin America. Synthetic medicinal chemistry efforts have provided an extensive number of chemodiverse hits at the “active-to-hit” stage. However, only a more limited number of these have been studied in vivo in models of Chagas’ disease. Herein, we survey some of the cantidates able to surpass the “hit-to-lead” stage discussing their limitations or merit to enter in clinical trials in the short term.

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