Release of Plasmodium sporozoites requires proteins with histone-fold dimerization domains

Chiara Currà; Renate Gessmann; Tomasino Pace; Leonardo Picci; Giulia Peruzzi; Vassiliki Varamogianni-Mamatsi; Lefteris Spanos; Célia R. S. Garcia; Roberta Spaccapelo; Marta Ponzi; Inga Siden-Kiamos

doi:10.1038/ncomms13846

Nature Communications (Dec 2016)

Release of Plasmodium sporozoites requires proteins with histone-fold dimerization domains

Chiara Currà,
Renate Gessmann,
Tomasino Pace,
Leonardo Picci,
Giulia Peruzzi,
Vassiliki Varamogianni-Mamatsi,
Lefteris Spanos,
Célia R. S. Garcia,
Roberta Spaccapelo,
Marta Ponzi,
Inga Siden-Kiamos

Affiliations

Chiara Currà: Foundation for Research and Technology—Hellas, Institute of Molecular Biology and Biotechnology
Renate Gessmann: Foundation for Research and Technology—Hellas, Institute of Molecular Biology and Biotechnology
Tomasino Pace: Dipartimento di Malattie Infettive, Istituto Superiore di Sanità, Parassitarie ed Immunomediate
Leonardo Picci: Dipartimento di Malattie Infettive, Istituto Superiore di Sanità, Parassitarie ed Immunomediate
Giulia Peruzzi: Department of Experimental Medicine, University of Perugia
Vassiliki Varamogianni-Mamatsi: Foundation for Research and Technology—Hellas, Institute of Molecular Biology and Biotechnology
Lefteris Spanos: Foundation for Research and Technology—Hellas, Institute of Molecular Biology and Biotechnology
Célia R. S. Garcia: Departamento de Fisiologia, Instituto de Biociências, Universidade de São Paulo
Roberta Spaccapelo: Department of Experimental Medicine, University of Perugia
Marta Ponzi: Dipartimento di Malattie Infettive, Istituto Superiore di Sanità, Parassitarie ed Immunomediate
Inga Siden-Kiamos: Foundation for Research and Technology—Hellas, Institute of Molecular Biology and Biotechnology

DOI: https://doi.org/10.1038/ncomms13846
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 9

Abstract

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Oocyst rupture and release of malaria sporozoites is needed for transmission of parasites from vector to humans. Here the authors identify two proteins, which they name ORP1 and ORP2, that form heterodimers and are required for oocyst rupture.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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