Nature Communications (Jan 2018)

Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics

  • David C. Earl,
  • P. Brent Ferrell,
  • Nalin Leelatian,
  • Jordan T. Froese,
  • Benjamin J. Reisman,
  • Jonathan M. Irish,
  • Brian O. Bachmann

DOI
https://doi.org/10.1038/s41467-017-02470-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Bioactive metabolites from plant and microbial extracts hold therapeutic potential. Here, the authors combine untargeted metabolomic arrays with flow cytometry-based single cell response profiling and identify metabolites with cell subset-specific activities in the bone marrow from an AML patient.