Ubiquitination of CLIP-170 family protein restrains polarized growth upon DNA replication stress

Xi Wang; Fan Zheng; Yuan-yuan Yi; Gao-yuan Wang; Li-xin Hong; Dannel McCollum; Chuanhai Fu; Yamei Wang; Quan-wen Jin

doi:10.1038/s41467-022-33311-y

Nature Communications (Sep 2022)

Ubiquitination of CLIP-170 family protein restrains polarized growth upon DNA replication stress

Xi Wang,
Fan Zheng,
Yuan-yuan Yi,
Gao-yuan Wang,
Li-xin Hong,
Dannel McCollum,
Chuanhai Fu,
Yamei Wang,
Quan-wen Jin

Affiliations

Xi Wang: State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University
Fan Zheng: School of Life Sciences, University of Science and Technology of China
Yuan-yuan Yi: State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University
Gao-yuan Wang: State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University
Li-xin Hong: State Key Laboratory of Cellular Stress Biology, School of Medicine, Faculty of Medicine and Life Sciences, Xiamen University
Dannel McCollum: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School
Chuanhai Fu: School of Life Sciences, University of Science and Technology of China
Yamei Wang: State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University
Quan-wen Jin: State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University

DOI: https://doi.org/10.1038/s41467-022-33311-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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The microtubule plus-end tracking protein Tip1 regulates microtubule dynamics and polar growth in fission yeast. Here the authors link the ubiquitination of Tip1 by ubiquitin ligase Dma1 to polarized growth inhibition upon DNA replication stress.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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