Journal of Hematology & Oncology (Jun 2009)

Co-existence of acute myeloid leukemia with multilineage dysplasia and Epstein-Barr virus-associated T-cell lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report

  • Suzuki Katsuya,
  • Itoyama Shinji,
  • Tamaru Jun-ichi,
  • Toyozumi Yasuo,
  • Nemoto Tomoe,
  • Sekiguchi Yasunobu,
  • Watanabe Reiko,
  • Hanzawa Kyoko,
  • Tokuhira Michihide,
  • Kameda Hideto,
  • Mori Shigehisa,
  • Kizaki Masahiro

DOI
https://doi.org/10.1186/1756-8722-2-27
Journal volume & issue
Vol. 2, no. 1
p. 27

Abstract

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Abstract Rheumatoid arthritis (RA) is an autoimmune disease mediated by inflammatory processes mainly at the joints. Recently, awareness of Epstein-Barr virus (EBV)-associated T-cell lymphoproliferative disorder (T-LPD) has been heightened for its association with methotraxate usage in RA patients. In the contrary, acute myeloid leukemia with multilineage dysplasia (AML-MLD) has never been documented to be present concomitantly with the above two conditions. In this report we present a case of an autopsy-proven co-existence of AML-MLD and EBV-associated T-LPD in a patient with RA.