Cognitive Impairment and Endoplasmic Reticulum Stress Induced by Repeated Short-Term Sevoflurane Exposure in Early Life of Rats

Fu-Yi Shen; Ying-Cai Song; Fei Guo; Zhen-Dong Xu; Qian Li; Bing Zhang; Bing Zhang; Bing Zhang; Yu-Qin Ma; Yu-Qin Ma; Yue-Qi Zhang; Rong Lin; Yang Li; Zhi-Qiang Liu

doi:10.3389/fpsyt.2018.00332

Frontiers in Psychiatry (Aug 2018)

Cognitive Impairment and Endoplasmic Reticulum Stress Induced by Repeated Short-Term Sevoflurane Exposure in Early Life of Rats

Fu-Yi Shen,
Ying-Cai Song,
Fei Guo,
Zhen-Dong Xu,
Qian Li,
Bing Zhang,
Bing Zhang,
Bing Zhang,
Yu-Qin Ma,
Yu-Qin Ma,
Yue-Qi Zhang,
Rong Lin,
Yang Li,
Zhi-Qiang Liu

Affiliations

Fu-Yi Shen: Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China
Ying-Cai Song: Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China
Fei Guo: Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
Zhen-Dong Xu: Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China
Qian Li: Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China
Bing Zhang: Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China
Bing Zhang: Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
Bing Zhang: University of Chinese Academy of Sciences, Beijing, China
Yu-Qin Ma: Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
Yu-Qin Ma: University of Chinese Academy of Sciences, Beijing, China
Yue-Qi Zhang: Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China
Rong Lin: Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China
Yang Li: Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
Zhi-Qiang Liu: Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China

DOI: https://doi.org/10.3389/fpsyt.2018.00332
Journal volume & issue: Vol. 9

Abstract

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Sevoflurane is one of the most commonly used volatile anaesthetics for children, but the safety of prolonged or repeated clinical use of sevoflurane in infants or children is controversial. Here, we investigated the effects of sevoflurane on rats in early life and the time scale of those effects. Our behavioral results indicated that repeated short-term exposure of new-born rats to sevoflurane caused learning and memory impairment, while a single exposure of rats to sevoflurane was relatively safe. Further mechanistic investigation revealed that repeated sevoflurane exposure impaired long-term potentiation (LTP), downregulated the expression of certain synaptogenesis-related proteins (GluR1, PSD95) and upregulated proteins related to endoplasmic reticulum (ER) stress in the hippocampus. An ER stress inhibitor, tauroursodeoxycholic acid (TUDCA), reversed the changes in the levels of synaptic plasticity proteins. Our results provide new evidence for the clinical concerns regarding repeated sevoflurane anesthesia.

Published in Frontiers in Psychiatry

ISSN: 1664-0640 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system: Psychiatry
Website: https://www.frontiersin.org/journals/psychiatry

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