Nature Communications (Jan 2020)

Identification of distinct maturation steps involved in human 40S ribosomal subunit biosynthesis

  • Blanca Nieto,
  • Sonia G. Gaspar,
  • Giulia Moriggi,
  • Dimitri G. Pestov,
  • Xosé R. Bustelo,
  • Mercedes Dosil

DOI
https://doi.org/10.1038/s41467-019-13990-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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Ribosome synthesis is a complex multi-step process. Here the authors present a method that allows the efficient isolation and characterization of the preribosomal complexes formed along the entire ribosome synthesis pathway in human cells.