Research advances Progress in the pathogenesis of IgA nephropathy

Abstract

As the most common primary glomerular disease in the world, IgA nephropathy (IgAN) is one of the major causes of end-stage renal disease (ESRD). With the in-depth studies of IgAN, researchers have gradually clarified the important roles of galactose-deficient IgA1 (Gd-IgA1) production, gut microbiome dysbacteriosis, genetic susceptibility and immune system abnormalities in the pathogenesis of IgAN. Therefore this review summarized the latest researches based upon the four-hit hypothesis of IgAN, dysbacteriosis, genetics and immunological mechanism and provides comprehensive perspectives for understanding the multidimensional factors of this disease.

Keywords

• glomerulonephritis, iga
• pathogenesis
• genetics
• immunology
• complement system
• dysbacteriosis