Nature Communications (May 2016)

The fast-recycling receptor Megalin defines the apical recycling pathway of epithelial cells

  • Andres E. Perez Bay,
  • Ryan Schreiner,
  • Ignacio Benedicto,
  • Maria Paz Marzolo,
  • Jason Banfelder,
  • Alan M. Weinstein,
  • Enrique J. Rodriguez-Boulan

DOI
https://doi.org/10.1038/ncomms11550
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 15

Abstract

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Basolateral recycling and transcytotic pathways in epithelial cells are defined by specific markers, however the apical recycling pathway is poorly understood. Perez Bay et al. show that Megalin is a marker for this pathway, which intersects with the other routes in shared perinuclear recycling endosomes.