IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses

Chang-Min Lee; Chuan Hua He; Adel M. Nour; Yang Zhou; Bing Ma; Jin Wook Park; Kyung Hee Kim; Charles Dela Cruz; Lokesh Sharma; Mahmoud L. Nasr; Yorgo Modis; Chun Geun Lee; Jack A. Elias

doi:10.1038/ncomms12752

Nature Communications (Sep 2016)

IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses

Chang-Min Lee,
Chuan Hua He,
Adel M. Nour,
Yang Zhou,
Bing Ma,
Jin Wook Park,
Kyung Hee Kim,
Charles Dela Cruz,
Lokesh Sharma,
Mahmoud L. Nasr,
Yorgo Modis,
Chun Geun Lee,
Jack A. Elias

Affiliations

Chang-Min Lee: Department of Molecular Microbiology and Immunology, Brown University
Chuan Hua He: Department of Molecular Microbiology and Immunology, Brown University
Adel M. Nour: Department of Molecular Microbiology and Immunology, Brown University
Yang Zhou: Department of Molecular Microbiology and Immunology, Brown University
Bing Ma: Department of Molecular Microbiology and Immunology, Brown University
Jin Wook Park: Department of Molecular Microbiology and Immunology, Brown University
Kyung Hee Kim: Division of Cardiology, Emory University School of Medicine
Charles Dela Cruz: Department of Medicine, Section of Pulmonary and Critical Care and Sleep Medicine, Yale University School of Medicine
Lokesh Sharma: Department of Medicine, Section of Pulmonary and Critical Care and Sleep Medicine, Yale University School of Medicine
Mahmoud L. Nasr: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Yorgo Modis: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Chun Geun Lee: Department of Molecular Microbiology and Immunology, Brown University
Jack A. Elias: Department of Molecular Microbiology and Immunology, Brown University

DOI: https://doi.org/10.1038/ncomms12752
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

Read online

Chitinase 3-like 1 regulates cell death, inflammation and tissue remodelling via IL-13receptorα2. Here, the authors show that TMEM219 is a IL-13Rα2 co-receptor and modulates oxidant-induced apoptosis and lung injury, melanoma metastasis and TGF-β1 signalling, downstream of Chi3l1-IL-13Rα2.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal