The altered circadian pattern of basal insulin requirements – an early marker of autoimmune polyendocrine syndromes in type 1 diabetes mellitus

Abstract

Objectives. The purpose of the present paper is to propose and introduce novel biomarkers of autoimmune polyendocrine syndromes that are relevant to the early diagnosis and optimal medical management of the patients who already suffer from type 1 diabetes mellitus.

Keywords

• type 1 diabetes mellitus
• hypoglycemia
• autoimmune polyendocrine syndromes
• insulin
• hypothyroidism
• addison disease