A mouse tissue transcription factor atlas

Quan Zhou; Mingwei Liu; Xia Xia; Tongqing Gong; Jinwen Feng; Wanlin Liu; Yang Liu; Bei Zhen; Yi Wang; Chen Ding; Jun Qin

doi:10.1038/ncomms15089

Nature Communications (Apr 2017)

A mouse tissue transcription factor atlas

Quan Zhou,
Mingwei Liu,
Xia Xia,
Tongqing Gong,
Jinwen Feng,
Wanlin Liu,
Yang Liu,
Bei Zhen,
Yi Wang,
Chen Ding,
Jun Qin

Affiliations

Quan Zhou: State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine; National Center for Protein Sciences (The PHOENIX Center, Beijing)
Mingwei Liu: State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine; National Center for Protein Sciences (The PHOENIX Center, Beijing)
Xia Xia: State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine; National Center for Protein Sciences (The PHOENIX Center, Beijing)
Tongqing Gong: State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine; National Center for Protein Sciences (The PHOENIX Center, Beijing)
Jinwen Feng: State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine; National Center for Protein Sciences (The PHOENIX Center, Beijing)
Wanlin Liu: State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine; National Center for Protein Sciences (The PHOENIX Center, Beijing)
Yang Liu: State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institutes of Biomedical Sciences, Fudan University
Bei Zhen: State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine; National Center for Protein Sciences (The PHOENIX Center, Beijing)
Yi Wang: Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Department of Molecular and Cellular Biology, Alkek Center for Molecular Discovery, Baylor College of Medicine
Chen Ding: State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine; National Center for Protein Sciences (The PHOENIX Center, Beijing)
Jun Qin: State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine; National Center for Protein Sciences (The PHOENIX Center, Beijing)

DOI: https://doi.org/10.1038/ncomms15089
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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While we have abundant data for transcription factor (TF) binding sites and TF expression at the mRNA level, our knowledge of TFs at the protein level and their DNA-binding activities is sparser. Here, the authors address this by using the catTFRE approach to profile active TFs in 24 adult and 8 fetal mouse tissues, and presenting the TF networks in major mouse organs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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