The Blood Plasma Lipidomic Profile in Atherosclerosis of the Brachiocephalic Arteries
Anastasiia Lomonosova,
Daria Gognieva,
Aleksandr Suvorov,
Artemy Silantyev,
Alina Abasheva,
Yana Vasina,
Magomed Abdullaev,
Anna Nartova,
Nikolay Eroshchenko,
Viktoriia Kazakova,
Roman Komarov,
Andrey Dzyundzya,
Elena Danilova,
Dmitry Shchekochikhin,
Philipp Kopylov
Affiliations
Anastasiia Lomonosova
World-Class Research Center «Digital Biodesign and Personalized Healthcare», I.M. Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia
Daria Gognieva
World-Class Research Center «Digital Biodesign and Personalized Healthcare», I.M. Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia
Aleksandr Suvorov
World-Class Research Center «Digital Biodesign and Personalized Healthcare», I.M. Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia
Artemy Silantyev
World-Class Research Center «Digital Biodesign and Personalized Healthcare», I.M. Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia
Alina Abasheva
World-Class Research Center «Digital Biodesign and Personalized Healthcare», I.M. Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia
Yana Vasina
World-Class Research Center «Digital Biodesign and Personalized Healthcare», I.M. Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia
Magomed Abdullaev
World-Class Research Center «Digital Biodesign and Personalized Healthcare», I.M. Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia
Anna Nartova
World-Class Research Center «Digital Biodesign and Personalized Healthcare», I.M. Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia
Nikolay Eroshchenko
Laboratory of Molecular Modeling and Chemistry of Natural Compounds, Institute of Molecular Theranostics, Scientific and Technological Park of Biomedicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia
Viktoriia Kazakova
Laboratory of Pathophysiology Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia
Roman Komarov
Department of Cardiovascular Surgery, Institute for Professional Education, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia
Andrey Dzyundzya
Department of Cardiovascular Surgery, Institute for Professional Education, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia
Elena Danilova
Laboratory of Molecular Modeling and Chemistry of Natural Compounds, Institute of Molecular Theranostics, Scientific and Technological Park of Biomedicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia
Dmitry Shchekochikhin
Department of Cardiology, Functional and Ultrasound Diagnostics, N.V. Sklifosovsky Institute for Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia
Philipp Kopylov
World-Class Research Center «Digital Biodesign and Personalized Healthcare», I.M. Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia
According to the World Health Organization, ischemic stroke is the second leading cause of death in the world. Frequently, it is caused by brachiocephalic artery (BCA) atherosclerosis. Timely detection of atherosclerosis and its unstable course can allow for a timely response to potentially dangerous changes and reduce the risk of vascular complications. Omics technologies allow us to identify new biomarkers that we can use in diagnosing diseases. This research included 90 blood plasma samples. The study group comprised 52 patients with severe atherosclerotic lesions BCA, and the control group comprised 38 patients with no BCA atherosclerosis. Targeted and panoramic lipidomic profiling of their blood plasma was carried out. There was a statistically significant difference (p p value 2. Unfortunately, we did not observe significant differences according to the established plasma panoramic lipidome criteria between patients with stable and unstable plaques. Omics technologies allow us to obtain data about any changes in the body. According to our data, statistically significant differences in lipidomic profiling were obtained when comparing groups with or without BCA atherosclerosis.