血管性帕金森综合征鉴别诊断的影像学研究进展 Advances of Imaging in the Differential Diagnosis of Vascular Parkinsonism

Abstract

血管性帕金森综合征（vascular parkinsonism，VP）是临床上常见的继发性帕金森综合征，目前VP临床诊断和鉴别诊断的准确率较低，影响其临床治疗和预后。在临床实践中，影像学常用于VP的诊断。近年来多模态MRI和分子影像成像及分析技术等影像学技术的进展为提高VP的诊断和鉴别诊断准确率提供了客观手段。本文就前沿影像学技术在VP与原发性帕金森病以及其他非典型帕金森综合征鉴别诊断领域的研究进展进行综述，以期为VP的诊断和鉴别诊断提供新的思路。 Abstract: Vascular parkinsonism is a common secondary parkinsonism. At present, the accuracy of diagnosis and differential diagnosis of vascular parkinsonism is low, which affects its treatment and prognosis. Imaging is commonly used in clinical practice to diagnose vascular parkinsonism. In recent years, the advance of multimodal MRI and molecular imaging and analysis technology has provided objective methods to improve the accuracy of diagnosis and differential diagnosis of vascular parkinsonism. This paper reviews the latest progress of various cutting-edge imaging techniques in the differential diagnosis of vascular parkinsonism from idiopathic Parkinson’s disease and other atypical parkinsonisms, hoping to provide new ideas for the diagnosis and differential diagnosis of vascular parkinsonism.

Keywords

• 血管性帕金森综合征
• 高分辨结构像
• 弥散张量成像
• 磁敏感加权成像
• 神经黑色素敏感成像
• 分子影像
• vascular parkinsonism
• high-resolution structural imaging
• diffusion tensor imaging
• susceptibility weighted imaging
• neuromelanin sensitive magnetic resonance imaging
• molecular imaging