Frontiers in Neural Circuits (Jan 2014)

Genesis of interictal spikes in the CA1: A computational investigation

  • Shivakeshavan eRatnadurai Giridharan,
  • Roxana A Stefanescu,
  • Pramod P Khargonekar,
  • Paul R Carney,
  • Paul R Carney,
  • Sachin S Talathi,
  • Sachin S Talathi,
  • Sachin S Talathi

DOI
https://doi.org/10.3389/fncir.2014.00002
Journal volume & issue
Vol. 8

Abstract

Read online

Interictal spikes (IISs) are spontaneous high amplitude, short time duration (80%) receives a barrage of quasi-synchronous afferent input via the SC. However, as we increase the recurrent connectivity of the CA1 (>40%); mimicking sprouting in a pathological CA1 network), the CA1 can exhibit IIS even in the absence of a barrage of quasi-synchronous afferents from the SC (input occurring within temporal window $>$80 ms) and a low fraction of CA1 Py cells (approximately 30%) receiving SC input. We also find that in the presence of Poisson distributed random (asynchronous) input via SC, the CA1 network generates spontaneous periodic IISs (approximately 3 Hz) for high degrees of recurrent Py connectivity (>70%). Our investigations find that spontaneous IISs closely depend on the degree of the network's intrinsic excitability.

Keywords