Chemical Constituents from Soft Coral <i>Clavularia</i> spp. Demonstrate Antiproliferative Effects on Oral Cancer Cells
Ming-Ya Cheng,
Ya-Ting Chuang,
Hsueh-Wei Chang,
Zheng-Yu Lin,
Ching-Yeu Chen,
Yuan-Bin Cheng
Affiliations
Ming-Ya Cheng
Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan
Ya-Ting Chuang
Department of Biomedical Science and Environmental Biology, PhD Program in Life Sciences, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
Hsueh-Wei Chang
Department of Biomedical Science and Environmental Biology, PhD Program in Life Sciences, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
Zheng-Yu Lin
Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan
Ching-Yeu Chen
Department of Physical Therapy, Tzu-Hui Institute of Technology, Pingtung 92641, Taiwan
Yuan-Bin Cheng
Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan
Five new eudensamane-type sesquiterpene lactones, clasamanes A–E (1–5), three new dolabellane-type diterpenes, clabellanes A–C (6–8), and fifteen known compounds (9–23) were isolated from the ethanolic extract of Taiwanese soft coral Clavularia spp. The structures of all undescribed components (1–8) were determined by analysis of IR, mass, NMR, and UV spectroscopic data. The absolute configuration of new compounds was determined by using circular dichroism and DP4+ calculations. The cytotoxic activities of all isolated marine natural products were evaluated. Compound 7 showed a significant cytotoxic effect against oral cancer cell line (Ca9-22) with an IC50 value of 7.26 ± 0.17 μg/mL.
