Nature Communications (Feb 2021)

Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation

  • Sau Yee Kok,
  • Hiroko Oshima,
  • Kei Takahashi,
  • Mizuho Nakayama,
  • Kazuhiro Murakami,
  • Hiroki R. Ueda,
  • Kohei Miyazono,
  • Masanobu Oshima

DOI
https://doi.org/10.1038/s41467-021-21160-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Cancer cell clusters metastasize to distant organ by polyclonal manner. Here, the authors show that malignant subclone induces fibrotic niche generation in the liver by hepatic stellate cell activation, supporting survival and colonization of non-metastatic cells to develop polyclonal metastasis.