Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation

Sau Yee Kok; Hiroko Oshima; Kei Takahashi; Mizuho Nakayama; Kazuhiro Murakami; Hiroki R. Ueda; Kohei Miyazono; Masanobu Oshima

doi:10.1038/s41467-021-21160-0

Nature Communications (Feb 2021)

Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation

Sau Yee Kok,
Hiroko Oshima,
Kei Takahashi,
Mizuho Nakayama,
Kazuhiro Murakami,
Hiroki R. Ueda,
Kohei Miyazono,
Masanobu Oshima

Affiliations

Sau Yee Kok: Division of Genetics, Cancer Research Institute, Kanazawa University
Hiroko Oshima: Division of Genetics, Cancer Research Institute, Kanazawa University
Kei Takahashi: Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo
Mizuho Nakayama: Division of Genetics, Cancer Research Institute, Kanazawa University
Kazuhiro Murakami: Division of Epithelial Stem Cell Biology, Cancer Research Institute, Kanazawa University
Hiroki R. Ueda: Department of Systems Pharmacology, The University of Tokyo
Kohei Miyazono: Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo
Masanobu Oshima: Division of Genetics, Cancer Research Institute, Kanazawa University

DOI: https://doi.org/10.1038/s41467-021-21160-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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Cancer cell clusters metastasize to distant organ by polyclonal manner. Here, the authors show that malignant subclone induces fibrotic niche generation in the liver by hepatic stellate cell activation, supporting survival and colonization of non-metastatic cells to develop polyclonal metastasis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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