Radical carbonylations using a continuous microflow system

Abstract

Radical-based carbonylation reactions of alkyl halides were conducted in a microflow reactor under pressurized carbon monoxide gas. Good to excellent yields of carbonylated products were obtained via radical formylation, carbonylative cyclization and three-component coupling reactions, using tributyltin hydride or TTMSS as a radical mediator.

Keywords

• continuous flow system
• microreactor
• radical carbonylation
• radical mediator
• V-65