The Roles of Innate Immune Cells in Atopic Dermatitis

Abstract

Background: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by recurrent eczematous lesions and severe pruritus. The economic burden and time penalty caused by the relapse of AD reduce patients’ life quality. Summary: AD has complex pathogenesis, including genetic disorders, epidermal barrier dysfunction, abnormal immune responses, microbial dysbiosis of the skin, and environmental factors. Recently, the role of innate immune cells in AD has attracted considerable attention. This review highlighted recent findings on innate immune cells in the onset and progression of AD. Key Messages: Innate immune cells play essential roles in the pathogenesis of AD and enough attention should be given for treating AD from the perspective of innate immunity in clinics.

Keywords

• alarmins
• damage-associated molecular patterns
• pathogen-associated molecular patterns
• prrs
• pruritus
• adaptive immunity
• innate immunity
• innate immune cells
• atopic dermatitis