PLoS ONE (Jan 2012)

miR-26b promotes granulosa cell apoptosis by targeting ATM during follicular atresia in porcine ovary.

  • Fei Lin,
  • Ran Li,
  • Zeng Xiang Pan,
  • Bo Zhou,
  • De Bing Yu,
  • Xu Guang Wang,
  • Xue Shan Ma,
  • Jing Han,
  • Ming Shen,
  • Hong Lin Liu

DOI
https://doi.org/10.1371/journal.pone.0038640
Journal volume & issue
Vol. 7, no. 6
p. e38640

Abstract

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More than 99% of ovarian follicles undergo atresia in mammals, but the mechanism of follicular atresia remains to be elucidated. In this study, we explored microRNA (miRNA) regulation of follicular atresia in porcine ovary. A miRNA expression profile was constructed for healthy, early atretic, and progressively atretic follicles, and the differentially expressed miRNAs were selected and analyzed. We found that miR-26b, which was upregulated during follicular atresia, increased the number of DNA breaks and promoted granulosa cell apoptosis by targeting the ataxia telangiectasia mutated gene directly in vitro.