Divergent wiring of repressive and active chromatin interactions between mouse embryonic and trophoblast lineages

Stefan Schoenfelder; Borbala Mifsud; Claire E. Senner; Christopher D. Todd; Stephanie Chrysanthou; Elodie Darbo; Myriam Hemberger; Miguel R. Branco

doi:10.1038/s41467-018-06666-4

Nature Communications (Oct 2018)

Divergent wiring of repressive and active chromatin interactions between mouse embryonic and trophoblast lineages

Stefan Schoenfelder,
Borbala Mifsud,
Claire E. Senner,
Christopher D. Todd,
Stephanie Chrysanthou,
Elodie Darbo,
Myriam Hemberger,
Miguel R. Branco

Affiliations

Stefan Schoenfelder: Nuclear Dynamics Programme, Babraham Institute
Borbala Mifsud: William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, QMUL
Claire E. Senner: Epigenetics Programme, Babraham Institute
Christopher D. Todd: Blizard Institute, Barts and The London School of Medicine and Dentistry, QMUL
Stephanie Chrysanthou: Epigenetics Programme, Babraham Institute
Elodie Darbo: Bordeaux Bioinformatics Center
Myriam Hemberger: Epigenetics Programme, Babraham Institute
Miguel R. Branco: Blizard Institute, Barts and The London School of Medicine and Dentistry, QMUL

DOI: https://doi.org/10.1038/s41467-018-06666-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

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The role of the genome structure in the establishment of the embryonic and trophoblast lineages is still not well understood. Here the authors perform promoter capture Hi-C in mouse trophoblast and embryonic stem cells and find divergent networks of repressive and active chromatin interactions between the two lineages.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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