Study of Wound Dressing Material Coated With Natural Extracts of Leaf Solution Enhanced With Recombinant Human Epidermal Growth Factor (REGEN-DTM 150)

Abstract

In the part of work, the leave extracts of aloe vera, piper betel, and neem leaf were prepared and coated on bamboo fiber-based material for wound dressing applications. The fabrics coated with different compositions of the natural extract were enhanced with recombinant human epidermal growth factor (REGEN-D™ 150). The FTIR confirms the presence of alcoholic and phenolic group which were responsible for antibacterial activity. The SEM morphology of the developed dressing material was porous nature and more suitable for the process of curing wound. In antimicrobial tests, the zone of incubation of Escherichia coli and Staphylococcus aureus ranges from 18 to 22 mm. In vivo study using albino rats induced with diabetes reveals that the wound healing rate is increased in the range of 25–54% compared to a negative control group.

Keywords

• antibacterial
• antimicrobial
• bamboo
• natural extract
• physical properties
• wound dressing