BMC Cancer (Apr 2024)

Deep learning-assisted diagnosis of benign and malignant parotid tumors based on ultrasound: a retrospective study

  • Tian Jiang,
  • Chen Chen,
  • Yahan Zhou,
  • Shenzhou Cai,
  • Yuqi Yan,
  • Lin Sui,
  • Min Lai,
  • Mei Song,
  • Xi Zhu,
  • Qianmeng Pan,
  • Hui Wang,
  • Xiayi Chen,
  • Kai Wang,
  • Jing Xiong,
  • Liyu Chen,
  • Dong Xu

DOI
https://doi.org/10.1186/s12885-024-12277-8
Journal volume & issue
Vol. 24, no. 1
pp. 1 – 12

Abstract

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Abstract Background To develop a deep learning(DL) model utilizing ultrasound images, and evaluate its efficacy in distinguishing between benign and malignant parotid tumors (PTs), as well as its practicality in assisting clinicians with accurate diagnosis. Methods A total of 2211 ultrasound images of 980 pathologically confirmed PTs (Training set: n = 721; Validation set: n = 82; Internal-test set: n = 89; External-test set: n = 88) from 907 patients were retrospectively included in this study. The optimal model was selected and the diagnostic performance evaluation is conducted by utilizing the area under curve (AUC) of the receiver-operating characteristic(ROC) based on five different DL networks constructed at varying depths. Furthermore, a comparison of different seniority radiologists was made in the presence of the optimal auxiliary diagnosis model. Additionally, the diagnostic confusion matrix of the optimal model was calculated, and an analysis and summary of misjudged cases’ characteristics were conducted. Results The Resnet18 demonstrated superior diagnostic performance, with an AUC value of 0.947, accuracy of 88.5%, sensitivity of 78.2%, and specificity of 92.7% in internal-test set, and with an AUC value of 0.925, accuracy of 89.8%, sensitivity of 83.3%, and specificity of 90.6% in external-test set. The PTs were subjectively assessed twice by six radiologists, both with and without the assisted of the model. With the assisted of the model, both junior and senior radiologists demonstrated enhanced diagnostic performance. In the internal-test set, there was an increase in AUC values by 0.062 and 0.082 for junior radiologists respectively, while senior radiologists experienced an improvement of 0.066 and 0.106 in their respective AUC values. Conclusions The DL model based on ultrasound images demonstrates exceptional capability in distinguishing between benign and malignant PTs, thereby assisting radiologists of varying expertise levels to achieve heightened diagnostic performance, and serve as a noninvasive imaging adjunct diagnostic method for clinical purposes.

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