Clinical Impact of CD25/CD123 Coexpression in Adult B-Cell Acute Lymphoblastic Leukemia Patients

Salah Aref; Mohamed El Agdar; Nada Khaled; Lamyaa Ibrahim; Mohamed S. El-Ghonemy

doi:10.1155/2020/9545717

Advances in Hematology (Jan 2020)

Clinical Impact of CD25/CD123 Coexpression in Adult B-Cell Acute Lymphoblastic Leukemia Patients

Salah Aref,
Mohamed El Agdar,
Nada Khaled,
Lamyaa Ibrahim,
Mohamed S. El-Ghonemy

Affiliations

Salah Aref: Hematology Unit, Clinical Pathology Department, Oncology Center Mansoura University (OCMU), Mansoura University, Mansoura, Egypt
Mohamed El Agdar: Hematology Unit, Clinical Pathology Department, Oncology Center Mansoura University (OCMU), Mansoura University, Mansoura, Egypt
Nada Khaled: Hematology Unit, Clinical Pathology Department, Oncology Center Mansoura University (OCMU), Mansoura University, Mansoura, Egypt
Lamyaa Ibrahim: Hematology Unit, Clinical Pathology Department, Oncology Center Mansoura University (OCMU), Mansoura University, Mansoura, Egypt
Mohamed S. El-Ghonemy: Hematology Unit, Clinical Pathology Department, Oncology Center Mansoura University (OCMU), Mansoura University, Mansoura, Egypt

DOI: https://doi.org/10.1155/2020/9545717
Journal volume & issue: Vol. 2020

Abstract

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This study aimed to determine the clinical impact of CD25+/CD123+ coexpression in adult B-cell acute lymphoblastic leukemia (B-ALL) cases. One hundred and twenty newly diagnosed B-ALL patients (≤60 years old) were included in this study. CD123 and CD25 expression on leukemic blast cells were assessed using flow cytometry. CD25+/CD123+ coexpression was detected in 40/120 B-ALL patients (33.3%). All B-ALL patients showed CD25+/CD123+ coexpression had lower induction of remission response and shorter overall survival as compared to B-ALL cases lacking coexpression. In conclusion, CD25+/CD123+ positive coexpression is a reliable flow cytometry marker for prediction of the outcome of adult B-ALL patients and could be used as a novel parameter for risk stratification of adult B-ALL cases.

Published in Advances in Hematology

ISSN: 1687-9104 (Print); 1687-9112 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs
Website: https://onlinelibrary.wiley.com/journal/3793

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