Rainbow trout (Oncorhynchus mykiss) proteins as a source of antioxidant peptides with promising anticancer activity
M.F. Escamilla-Rosales,
E. Pérez-Escalante,
C.E. Jara-Gutiérrez,
P.A. Santana-Sepúlveda,
C.A. Álvarez-Álvarez,
A Castañeda-Ovando,
L.G. González-Olivares
Affiliations
M.F. Escamilla-Rosales
Instituto de Ciencias Básicas e Ingeniería, Área Académica de Química, Ciudad del, Conocimiento, Universidad Autónoma del Estado de Hidalgo, Mineral de la Reforma, Hidalgo 420390, Mexico
E. Pérez-Escalante
Instituto de Ciencias Básicas e Ingeniería, Área Académica de Química, Ciudad del, Conocimiento, Universidad Autónoma del Estado de Hidalgo, Mineral de la Reforma, Hidalgo 420390, Mexico
C.E. Jara-Gutiérrez
Centro interdisciplinario de investigación biomédica e ingeniería para la salud (MEDING), Escuela de Kinesiología, Facultad de Medicina, Universidad de Valparaíso, Valparaíso, Chile; Corresponding authors.
P.A. Santana-Sepúlveda
Instituto de Ciencias Aplicadas, Facultad de Ingeniería, Universidad Autónoma de Chile, El Llano Subercaseaux 2801, San Miguel, Santiago 891006, Chile
C.A. Álvarez-Álvarez
Laboratorio de Fisiología y Genética Marina, Centro de Estudios Avanzados en Zonas, Áridas, Larrondo 1281, Coquimbo 1780000, Chile
A Castañeda-Ovando
Instituto de Ciencias Básicas e Ingeniería, Área Académica de Química, Ciudad del, Conocimiento, Universidad Autónoma del Estado de Hidalgo, Mineral de la Reforma, Hidalgo 420390, Mexico
L.G. González-Olivares
Corresponding authors.; Instituto de Ciencias Básicas e Ingeniería, Área Académica de Química, Ciudad del, Conocimiento, Universidad Autónoma del Estado de Hidalgo, Mineral de la Reforma, Hidalgo 420390, Mexico
Fish production worldwide is aimed at muscle consumption, and this industry discards around 60 % of the fish in undervalued by-products. A widely consumed commercial species is the rainbow trout (O. mykiss), which has a consumption presence among commercial fish of 17 %. This makes it a significant species due to the amount of waste obtained after consumption. In addition, the protein content of muscle and by-products is relevant, as it is often a source of encrypted bioactive peptides, which can be released by hydrolytic mechanisms, such as enzymatic digestion, in vitro digestion, and microbial fermentation. Several studies have proved the bioactivity of peptides obtained from fish species that contain amino acid sequences with properties that interest human health. This article reviews the protein composition, the mechanism for obtaining peptides, action ways of antioxidant peptides, in silico sequences from the BIOPEP database, and their potential anticancer activity, contrasting with discoveries in other species and emphasizing the potential of O. mykiss proteins as a source for obtaining antioxidant peptides with anticancer capacity.
