Astragalus polysaccharides protects thapsigargin-induced endoplasmic reticulum stress in HT29 cells

Zheng Lie; Zhang Ya-Li; Chen Xuan; Chen De-Liang; Dai Yan-Cheng; Tang Zhi-Peng

doi:10.1515/biol-2019-0055

Open Life Sciences (Dec 2019)

Astragalus polysaccharides protects thapsigargin-induced endoplasmic reticulum stress in HT29 cells

Zheng Lie,
Zhang Ya-Li,
Chen Xuan,
Chen De-Liang,
Dai Yan-Cheng,
Tang Zhi-Peng

Affiliations

Zheng Lie: Institute of Digestive Diseases, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, 725 Wanping Road, Shanghai200032, China
Zhang Ya-Li: Institute of Digestive Diseases, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, 725 Wanping Road, Shanghai200032, China
Chen Xuan: Shanghai University of Traditional Chinese Medicine, Shanghai201203, China
Chen De-Liang: Institute of Digestive Diseases, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, 725 Wanping Road, Shanghai200032, China
Dai Yan-Cheng: Institute of Digestive Diseases, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, 725 Wanping Road, Shanghai200032, China
Tang Zhi-Peng: Institute of Digestive Diseases, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, 725 Wanping Road, Shanghai200032, China

DOI: https://doi.org/10.1515/biol-2019-0055
Journal volume & issue: Vol. 14, no. 1
pp. 494 – 501

Abstract

Read online

This study investigates the effect of astragalus polysaccharides (APS) in protecting against thapsigargin-induced endoplasmic reticulum (ER) stress in HT29 cells by suppressing the PERK-eIF2a signaling pathway.

Published in Open Life Sciences

ISSN: 2391-5412 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Science: Biology (General)
Website: http://www.degruyter.com/view/j/biol

About the journal

Abstract

Keywords