Clinical Features of Mycoplasma pneumoniae Infections in the 2010 Epidemic Season: Report of Two Cases with Unusual Presentations

Tomoaki Takei; Miyuki Morozumi; Hirohiko Ozaki; Hisayo Fujita; Kimiko Ubukata; Isshi Kobayashi; Keisuke Kadota; Takako Miyamae; Shumpei Yokota; Satoshi Iwata; Takashi Takahashi

doi:10.1016/j.pedneo.2012.11.016

Pediatrics and Neonatology (Dec 2013)

Clinical Features of Mycoplasma pneumoniae Infections in the 2010 Epidemic Season: Report of Two Cases with Unusual Presentations

Tomoaki Takei,
Miyuki Morozumi,
Hirohiko Ozaki,
Hisayo Fujita,
Kimiko Ubukata,
Isshi Kobayashi,
Keisuke Kadota,
Takako Miyamae,
Shumpei Yokota,
Satoshi Iwata,
Takashi Takahashi

Affiliations

Tomoaki Takei: Department of Pediatrics, Hiratsuka Kyosai Hospital, Kanagawa, Japan
Miyuki Morozumi: Laboratory of Molecular Epidemiology for Infectious Agents, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan
Hirohiko Ozaki: Laboratory of Infectious Diseases, Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan
Hisayo Fujita: Laboratory of Infectious Diseases, Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan
Kimiko Ubukata: Laboratory of Molecular Epidemiology for Infectious Agents, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan
Isshi Kobayashi: Department of Cardiology, Hiratsuka Kyosai Hspital, Kanagawa, Japan
Keisuke Kadota: Department of Pediatrics, Yokohama City University, Kanagawa, Japan
Takako Miyamae: Department of Pediatrics, Yokohama City University, Kanagawa, Japan
Shumpei Yokota: Department of Pediatrics, Yokohama City University, Kanagawa, Japan
Satoshi Iwata: Center for Infectious Diseases and Infection Control, Keio University, School of Medicine, Tokyo, Japan
Takashi Takahashi: Laboratory of Infectious Diseases, Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan

DOI: https://doi.org/10.1016/j.pedneo.2012.11.016
Journal volume & issue: Vol. 54, no. 6
pp. 402 – 405

Abstract

Read online

Mycoplasma pneumoniae (Mp) is one of the main pathogens causing community-acquired pneumonia, particularly in young individuals. Host immune response appears to play an important role in prolonged symptoms, as well as in the recent increasing prevalence of drug-resistant Mp isolated from patients. Case 1 had a prolonged clinical course caused by drug-resistant Mp and received steroid therapy despite Mp susceptibility to some antimicrobial agents. Serum cytokine profiles revealed elevation of interleukin-6/-10 and interferon-γ in acute phase. Case 2 had mycoplasmal myocarditis without any respiratory symptoms, which resolved spontaneously without the administration of any antimicrobial agent. These observations suggest that host immune response probably contributes to the etiology of Mp-associated complications.

Published in Pediatrics and Neonatology

ISSN: 1875-9572 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Pediatrics
Website: https://www.journals.elsevier.com/pediatrics-and-neonatology/

About the journal

Abstract

Keywords