Atherosclerotic coronary artery disease (CAD) is a leading cause of morbidity and mortality globally. Because of its remarkable technological advances, a coronary computed tomography angiography (CTA) is now a crucial imaging tool in the evaluation of patients with nonspecific acute and stable chest pain. This review article provides an overview of atherosclerotic CAD, the pros and cons of CTAs as compared to competing imaging modalities, and the potential remedies to overcome drawbacks of CTAs.