The Optimal Analgesic Method in Endometrial Sampling: Comparison of 4 Most Applied Methods Against Placebo

Abstract

INTRODUCTION[|]Operations performed with only local anesthesia may be extremely painful and discomfortable for patients. The present study aims to investigate the optimal analgesic method in endometrial sampling and fractional curettage procedures.[¤]METHODS[|]This prospective, randomized clinical study was conducted at our Clinic between March 2007 and December 2014. Two hundred fifty patients were randomized into five groups as follows: intrauterine saline group (group 1, n=50), paracervical lidocaine group (group 2, n=50), intrauterine lidocaine group (group 3, n=50), oral and vaginal misoprostol group (group4, n=50), oral misoprostol and 550 mg naproxen sodium group (group 5, n=50). All groups were evaluated by visual analogue scale (VAS) before the procedure, during the procedure and 30 minutes after the procedure.[¤]RESULTS[|]Assessment of increase in pain during the procedure showed that the paracervical lidocaine group and intrauterine lidocaine group were effective in providing mild pain (VAS: 0–2). These two groups were also effective to prevent maximal pain (VAS: 7–10). The paracervical lidocaine group had the lowest median VAS score was compared with all groups. [¤]DISCUSSION AND CONCLUSION[|]Effective analgesia for endometrial sampling and fractional curettage were provided with the paracervical lidocaine and intrauterine lidocaine administration. The procedure with the lowest median VAS score was paracervical lidocaine administration.[¤]

Keywords

• analgesia
• curettage
• endometrial neoplasms.