ABO genotypes and the risk of esophageal and gastric cancers
Yingxi Chen,
Nan Hu,
Linda Liao,
Kai Yu,
Xiao-Ou Shu,
Wei Zheng,
Jian-Min Yuan,
Woon-Puay Koh,
You-Lin Qiao,
Jin-Hu Fan,
Sanford M. Dawsey,
Neal D. Freedman,
Philip R. Taylor,
Alisa M. Goldstein,
Christian C. Abnet
Affiliations
Yingxi Chen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
Nan Hu
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
Linda Liao
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
Kai Yu
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
Xiao-Ou Shu
Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center
Wei Zheng
Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center
Jian-Min Yuan
UPMC Hillman Cancer Center, University of Pittsburgh
Woon-Puay Koh
Health Service and Systems Research, Duke-NUS Medical School
You-Lin Qiao
National Cancer Center, National Center for Cancer Clinical Research, The Cancer Institute, Chinese Academy of Medical Sciences/Peking Union Medical College
Jin-Hu Fan
National Cancer Center, National Center for Cancer Clinical Research, The Cancer Institute, Chinese Academy of Medical Sciences/Peking Union Medical College
Sanford M. Dawsey
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
Neal D. Freedman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
Philip R. Taylor
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
Alisa M. Goldstein
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
Christian C. Abnet
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
Abstract Background Blood type has been associated with the risk of gastric cancer, but few studies have examined the association with esophageal squamous cell carcinoma (ESCC). Methods We conducted a case-control study using genotyping data of Chinese individuals, including cases of 2022 ESCC, 1189 gastric cardia adenocarcinoma, 1161 gastric noncardia adenocarcinoma, and 2696 controls. Genetic blood type was imputed using three single nucleotide polymorphisms. We used logistic regression to examine the association between blood type and the risk of each cancer. Results Compared to blood type O, the risk of ESCC was significantly elevated for blood type B and AB, with the highest risk for type AB (OR, 95%CI: 1.34, 1.07–1.67). Analysis of genotype suggested that the association of ESCC was from carrying the B allele. Similarly, blood type was significantly associated with gastric noncardia adenocarcinoma (P < 0.001) with risk significantly elevated in type A (1.37, 1.14–1.65) and AB (1.44, 1.10–1.89) compared to type O. Blood type was not associated with gastric cardia adenocarcinoma (P = 0.13). Conclusions This study provides novel insights into the association between blood type and the risk of ESCC and restricted previously observed association to only gastric noncardia cancer, providing important evidence to clarify the pattern of association and suggesting mechanisms of action.
