Melanoma brain metastases that progress on BRAF-MEK inhibitors demonstrate resistance to ipilimumab-nivolumab that is associated with the Innate PD-1 Resistance Signature (IPRES)

• Shahneen Sandhu,
• Grant A McArthur,
• Kate Drummond,
• Alison Weppler,
• Tony Papenfuss,
• Amir Iravani,
• Belinda Lee,
• Richard J Young,
• Kortnye Smith,
• Peter Kar Han Lau,
• Breon Feran,
• Lorey Smith,
• Arian Lasocki,
• Ramyar Molania,
• Christopher Angel,
• Hanxian Aw Yeang,
• Ismael A Vergara,
• David Kok,
• Paul Joseph Neeson,
• Karen E Sheppard,
• Benjamin J Solomon

Affiliations

Shahneen Sandhu

Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

Grant A McArthur

Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

Kate Drummond

Department of Neurosurgery, The Royal Melbourne Hospital, Melbourne, Victoria, Australia

Alison Weppler

Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

Tony Papenfuss

Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia

Amir Iravani

Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia

Belinda Lee

Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

Richard J Young

Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

Kortnye Smith

Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

Peter Kar Han Lau

Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

Breon Feran

Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia

Lorey Smith

Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

Arian Lasocki

Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia

Ramyar Molania

Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia

Christopher Angel

Department of Histopathology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

Hanxian Aw Yeang

Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

Ismael A Vergara

Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

David Kok

Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

Paul Joseph Neeson

Cancer Immunology Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

Karen E Sheppard

Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

Benjamin J Solomon

Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia