Conformational and migrational dynamics of slipped-strand DNA three-way junctions containing trinucleotide repeats

Tianyu Hu; Michael J. Morten; Steven W. Magennis

doi:10.1038/s41467-020-20426-3

Nature Communications (Jan 2021)

Conformational and migrational dynamics of slipped-strand DNA three-way junctions containing trinucleotide repeats

Tianyu Hu,
Michael J. Morten,
Steven W. Magennis

Affiliations

Tianyu Hu: School of Chemistry, University of Glasgow
Michael J. Morten: School of Chemistry, University of Glasgow
Steven W. Magennis: School of Chemistry, University of Glasgow

DOI: https://doi.org/10.1038/s41467-020-20426-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 8

Abstract

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DNA three-way junctions are branched structures formed during replication, repair, and recombination, and are involved in models of repeat expansion. Here the authors use single-molecule Förster resonance energy transfer to reveal the dynamics of DNA three-way junctions containing slip-outs composed of CAG or CTG repeats.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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