Normal values of nasal NO and exhaled NO in young Chinese people aged 9 – 22 years

Abstract

Objective: To assess the normal levels of nasal nitric oxide (NNO) and fractional exhaled nitric oxide (FENO) in healthy Chinese young people, and to determine whether the obtained values were associated with age, sex, height, weight, BMI (body mass index) or BSA (body surface area). Methods: One hundred and twenty healthy people were selected from a total of 436 Chinese young people based on their answers to a questionnaire. An electrochemical analyzer (NIOX MINO system) was used to measure NNO and FENO. The relationship between NNO, FENO and age, sex, height, weight, BMI, BSA was analyzed using SPSS software. Results: The values of NNO were normal distributed (mean 273.5Â ppb; SD 112.3). The values of FENO were non-normally (Skewed) distributed (median: 14.00Â ppb; interquartile range: 7.00Â ppb). The obtained NNO values were independent of age, sex, height, weight, BMI and BSA, but were positively correlated to lnFENO (FENO log base e); lnFENO values were also independent of age, height, weight, BMI and BSA, but correlated with NNO and sex. Conclusions: NNO values positively correlate with lnFENO in healthy people and the levels of each may be predicted by the other. The results of this study are expected to serve as a reference for future studies in China. Keywords: Nitric oxide, Nasal cavity, Lower respiratory tract, Normal value, Healthy people