Peripheral blood CD4+CCR6+ compartment differentiates HIV-1 infected or seropositive elite controllers from long-term successfully treated individuals

Sara Svensson Akusjärvi; Shuba Krishnan; Bianca B. Jütte; Anoop T. Ambikan; Soham Gupta; Jimmy Esneider Rodriguez; Ákos Végvári; Maike Sperk; Piotr Nowak; Jan Vesterbacka; J. Peter Svensson; Anders Sönnerborg; Ujjwal Neogi

doi:10.1038/s42003-022-03315-x

Communications Biology (Apr 2022)

Peripheral blood CD4+CCR6+ compartment differentiates HIV-1 infected or seropositive elite controllers from long-term successfully treated individuals

Sara Svensson Akusjärvi,
Shuba Krishnan,
Bianca B. Jütte,
Anoop T. Ambikan,
Soham Gupta,
Jimmy Esneider Rodriguez,
Ákos Végvári,
Maike Sperk,
Piotr Nowak,
Jan Vesterbacka,
J. Peter Svensson,
Anders Sönnerborg,
Ujjwal Neogi

Affiliations

Sara Svensson Akusjärvi: Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura
Shuba Krishnan: Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura
Bianca B. Jütte: Department of Biosciences and Nutrition, Karolinska Institutet, Neo
Anoop T. Ambikan: Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura
Soham Gupta: Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura
Jimmy Esneider Rodriguez: Division of Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
Ákos Végvári: Division of Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
Maike Sperk: Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura
Piotr Nowak: Division of Infectious Disease, Department of Medicine Huddinge, Karolinska Institutet, I73, Karolinska University Hospital
Jan Vesterbacka: Division of Infectious Disease, Department of Medicine Huddinge, Karolinska Institutet, I73, Karolinska University Hospital
J. Peter Svensson: Department of Biosciences and Nutrition, Karolinska Institutet, Neo
Anders Sönnerborg: Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura
Ujjwal Neogi: Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, ANA Futura

DOI: https://doi.org/10.1038/s42003-022-03315-x
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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The expression profiles dynamics of several chemokine receptors are lower for people living with HIV-1 who naturally control the virus compared to those on suppressive antiretroviral therapy and HIV-negative controls, shedding light on the mechanisms of natural control of HIV-1 infection.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal