Научно-практическая ревматология (Jun 2011)
NEKhODZhKINSKIE LIMFOMY PRI REVMATIChESKIKh ZABOLEVANIYaKh
Abstract
Nekhodzhkinskie limfomy (NKhL), predstavlyayushchie soboi geterogennuyu gruppu opukholei iz limfoidnoi tkani, naibolee chasto (>90%) imeyut V-kletochnoe proiskhozhdenie. Vozmozhno, etot fakt obuslovlen osobennostyami V- kletochnogo immunnogo otveta. Tak, neobkhodimoe porazitel'noe raznoobrazie immunoglobulinov (Ig) po spetsifichnosti tsentrov svyazyvaniya s antigenom obespechivaetsya razlichnymi mekhanizmami, vklyuchayushchimi somaticheskii mutagenez, gennuyu konversiyu, rekombinatsiyu ryada gennykh segmentov, obrazuyushchikh polnyi V-gen (variabel'noi oblasti molekuly Ig).