Научно-практическая ревматология (Jun 2011)

NEKhODZhKINSKIE LIMFOMY PRI REVMATIChESKIKh ZABOLEVANIYaKh

  • O. A. Logvinenko,
  • V. I. Vasil'ev

DOI
https://doi.org/10.14412/1995-4484-2011-1464
Journal volume & issue
Vol. 49, no. 5
pp. 71 – 82

Abstract

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Nekhodzhkinskie limfomy (NKhL), predstavlyayushchie soboi geterogennuyu gruppu opukholei iz limfoidnoi tkani, naibolee chasto (>90%) imeyut V-kletochnoe proiskhozhdenie. Vozmozhno, etot fakt obuslovlen osobennostyami V- kletochnogo immunnogo otveta. Tak, neobkhodimoe porazitel'noe raznoobrazie immunoglobulinov (Ig) po spetsifichnosti tsentrov svyazyvaniya s antigenom obespechivaetsya razlichnymi mekhanizmami, vklyuchayushchimi somaticheskii mutagenez, gennuyu konversiyu, rekombinatsiyu ryada gennykh segmentov, obrazuyushchikh polnyi V-gen (variabel'noi oblasti molekuly Ig).