Nature Communications (Jan 2016)
In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics
- Xiangzhao Ai,
- Chris Jun Hui Ho,
- Junxin Aw,
- Amalina Binte Ebrahim Attia,
- Jing Mu,
- Yu Wang,
- Xiaoyong Wang,
- Yong Wang,
- Xiaogang Liu,
- Huabing Chen,
- Mingyuan Gao,
- Xiaoyuan Chen,
- Edwin K.L. Yeow,
- Gang Liu,
- Malini Olivo,
- Bengang Xing
Affiliations
- Xiangzhao Ai
- Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University
- Chris Jun Hui Ho
- Singapore Bioimaging Consortium, Agency for Science Technology and Research (A*STAR)
- Junxin Aw
- Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University
- Amalina Binte Ebrahim Attia
- Singapore Bioimaging Consortium, Agency for Science Technology and Research (A*STAR)
- Jing Mu
- Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University
- Yu Wang
- Department of Chemistry, National University of Singapore
- Xiaoyong Wang
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
- Yong Wang
- School of Radiation Medicine and Protection, Soochow University
- Xiaogang Liu
- Department of Chemistry, National University of Singapore
- Huabing Chen
- School of Radiation Medicine and Protection, Soochow University
- Mingyuan Gao
- School of Radiation Medicine and Protection, Soochow University
- Xiaoyuan Chen
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
- Edwin K.L. Yeow
- Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University
- Gang Liu
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
- Malini Olivo
- Singapore Bioimaging Consortium, Agency for Science Technology and Research (A*STAR)
- Bengang Xing
- Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University
- DOI
- https://doi.org/10.1038/ncomms10432
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 9
Abstract
Directing nanomedicines to desired locations - such as tumour sites - is difficult to achieve selectively. Here, the authors develop a method to covalently crosslink peptide-modified upconversion nanocrystals into tumour sites for photodynamic therapy and show in vivotumour inhibition in mice.
