Nature Communications (Jan 2020)
Genomic programming of IRF4-expressing human Langerhans cells
- Sofia Sirvent,
- Andres F. Vallejo,
- James Davies,
- Kalum Clayton,
- Zhiguo Wu,
- Jeongmin Woo,
- Jeremy Riddell,
- Virendra K. Chaudhri,
- Patrick Stumpf,
- Liliya Angelova Nazlamova,
- Gabrielle Wheway,
- Matthew Rose-Zerilli,
- Jonathan West,
- Mario Pujato,
- Xiaoting Chen,
- Christopher H. Woelk,
- Ben MacArthur,
- Michael Ardern-Jones,
- Peter S. Friedmann,
- Matthew T. Weirauch,
- Harinder Singh,
- Marta E. Polak
Affiliations
- Sofia Sirvent
- Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton
- Andres F. Vallejo
- Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton
- James Davies
- Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton
- Kalum Clayton
- Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton
- Zhiguo Wu
- Division of Immunobiology & Center for Systems Immunology, Cincinnati Children’s Hospital Medical Center
- Jeongmin Woo
- Samsung Genome Institute, Samsung Medical Center
- Jeremy Riddell
- Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center
- Virendra K. Chaudhri
- Division of Immunobiology & Center for Systems Immunology, Cincinnati Children’s Hospital Medical Center
- Patrick Stumpf
- Human Development and Health, Faculty of Medicine, University of Southampton
- Liliya Angelova Nazlamova
- Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton
- Gabrielle Wheway
- Human Development and Health, Faculty of Medicine, University of Southampton
- Matthew Rose-Zerilli
- Cancer Sciences, Faculty of Medicine, University of Southampton
- Jonathan West
- Cancer Sciences, Faculty of Medicine, University of Southampton
- Mario Pujato
- Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center
- Xiaoting Chen
- Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center
- Christopher H. Woelk
- Merck’s Exploratory Science Center
- Ben MacArthur
- Cancer Sciences, Faculty of Medicine, University of Southampton
- Michael Ardern-Jones
- Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton
- Peter S. Friedmann
- Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton
- Matthew T. Weirauch
- Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center
- Harinder Singh
- Division of Immunobiology & Center for Systems Immunology, Cincinnati Children’s Hospital Medical Center
- Marta E. Polak
- Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton
- DOI
- https://doi.org/10.1038/s41467-019-14125-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Langerhans cells (LC) can prime tolerogenic as well as immunogenic responses in the skin. Here the authors show, by transcriptomic, epigenetic and CRISPR editing analyses, that during LC migration and maturation the transcription factor IRF4 regulates expression of antigen presentation and co-stimulatory gene modules while attenuating inflammatory response genes.
