BMJ Open (Dec 2021)

Cohort profile: the Spanish Early-onset Colorectal Cancer (SECOC) cohort: a multicentre cohort study on the molecular basis of colorectal cancer among young individuals in Spain

  • Núria Malats,
  • Sabela Carballal,
  • María Pellisé,
  • Francesc Balaguer,
  • Victor Moreno,
  • Javier Rodriguez,
  • Teresa Ocaña,
  • José Perea,
  • Cristina Santos,
  • Eloy Espin,
  • Miriam Cuatrecasas,
  • Damian Garcia-Olmo,
  • Antonino Spinelli,
  • Lorena Moreno,
  • Lucía Inglada-Pérez,
  • Rogelio González-Sarmiento,
  • Miguel Urioste,
  • Enrique Pastor,
  • Julián Pérez-Pérez,
  • Jesus Fernandez,
  • Alejandro Forero,
  • Marc Marti,
  • Sergio Hernandez-Villafranca,
  • Pilar Orihuela,
  • Rosario Vidal Tocino,
  • Jose Antonio Alcazar,
  • Alfredo Vivas,
  • Cristina Narvaez,
  • Isabel Prieto,
  • Luis Asensio,
  • Irene López Rojo,
  • Sara Encinas Garcia,
  • Elena Hurtado,
  • Luis M Jiménez,
  • Fernando Jiménez,
  • Adriana Cavero,
  • Edurne Alvaro,
  • Maria Luisa Fuenmayor,
  • Marta Jiménez Toscano,
  • Mar Iglesias Comas,
  • Maria Daca,
  • Araceli Ballestero,
  • Javier Die Trill,
  • Gonzalo Sanz,
  • Rodrigo Sanz López,
  • Sirio Melone,
  • Jose A Rueda,
  • Lorena Brandariz,
  • Ignacio Valverde,
  • Jorge Arredondo,
  • Carlos Pastor,
  • Andreana N Holowatyj,
  • Mercedes Martínez Villacampa,
  • Jose Carlos Ruffinelli,
  • José A Sueda Orgaz,
  • Víctor Castellano Megías,
  • Susana Olmedillas-López,
  • Vicente Portugal,
  • María Arriba Domenech,
  • Isabel Peligros Gómez,
  • Cristina Rey Valcárcel,
  • Jaime Zorrilla Ortúzar,
  • Ariadna Sánchez,
  • Ana Ramírez de Molina,
  • Gonzalo Colmenarejo,
  • Isabel Espinosa-Salinas,
  • Lara Fernández,
  • Marta Gómez de Cedrón,
  • Luis Corchete,
  • Juan L García,
  • Paula García Vallés,
  • Ana B Hernández,
  • Abel J Martel,
  • Jéssica Pérez,
  • Ana Burdaspal,
  • Inés Rubio,
  • Amaya Villafañe,
  • Oscar Alonso,
  • Sara Encinas,
  • Ana Teijo,
  • Jorge Baixauli Fons,
  • Lucia Ceniceros Paredes,
  • Carlos Sánchez Justicia,
  • Jana Dziakova,
  • Sara Picazo Marín,
  • María Suárez Solís,
  • Jacinto García,
  • Lidia Estudillo,
  • Franco Marinello,
  • Miquel Kraft,
  • Stefania Landolfi,
  • Inmaculada Salces,
  • Sandra Tapial

DOI
https://doi.org/10.1136/bmjopen-2021-055409
Journal volume & issue
Vol. 11, no. 12

Abstract

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Purpose The Spanish Early-onset Colorectal Cancer (SECOC) study is a multicentre prospective cohort established in Spain to investigate the molecular basis of early-onset colorectal cancer (EOCRC), including metabolic alterations.Participants 220 patients with EOCRC have been enrolled since January 2019 through 18 centres across Spain. Individual-level data were collected by questionnaire, including lifestyle and other colorectal cancer-related factors. Medical record review was performed to capture clinical, histopathological and familial cancer history data. Biospecimen collection (blood, stool, tissue) at diagnosis and at various time points across treatment, as applicable, is also completed.Findings to date Participants had a median age of 44 years (range 14–49), and the majority are men (60%), with individuals age 40–49 years at EOCRC diagnosis being over-represented. Forty-three per cent of participants were diagnosed with a tumour in the rectosigmoid junction/rectum. Nearly two-thirds of EOCRC cases (64%) were diagnosed with advanced stage (III–IV) disease, and 28% of cases had no reported familial history of cancer.Future plans We are actively recruiting and observing participants; we plan to administer follow-up questionnaires and perform additional biospecimen collection. This prospective cohort offers a unique, rich resource for research on EOCRC aetiologies and will contribute to larger international efforts to disentangle the rising disease burden.