Nature Communications (Apr 2018)

Gold-catalyzed stereoselective cycloisomerization of allenoic acids for two types of common natural γ-butyrolactones

  • Jing Zhou,
  • Chunling Fu,
  • Shengming Ma

DOI
https://doi.org/10.1038/s41467-018-03894-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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Gamma-butyrolactones are widespread in Nature, however direct catalytic methods to access them are limited. Here, the authors report a gold-catalyzed cycloisomerization of allenoic acids to acces γ-butyrolactones and apply it to the asymmetric synthesis of xestospongienes E, F, G, and H and other naturally occurring lactones.