Enantioselective functionalization at the C4 position of pyridinium salts through NHC catalysis

Hangyeol Choi; Gangadhar Rao Mathi; Seonghyeok Hong; Sungwoo Hong

doi:10.1038/s41467-022-29462-7

Nature Communications (Apr 2022)

Enantioselective functionalization at the C4 position of pyridinium salts through NHC catalysis

Hangyeol Choi,
Gangadhar Rao Mathi,
Seonghyeok Hong,
Sungwoo Hong

Affiliations

Hangyeol Choi: Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST)
Gangadhar Rao Mathi: Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST)
Seonghyeok Hong: Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST)
Sungwoo Hong: Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST)

DOI: https://doi.org/10.1038/s41467-022-29462-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 8

Abstract

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A catalytic method for the enantioselective and C4-selective functionalization of pyridine derivatives is yet to be developed. Here the authors report an efficient method for the asymmetric β-pyridylations of enals that involve N-heterocyclic carbene (NHC) catalysis with excellent control over enantioselectivity and pyridyl C4-selectivity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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