Nature Communications (Jul 2022)
Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life
- Jaco Selle,
- Katharina Dinger,
- Vanessa Jentgen,
- Daniela Zanetti,
- Johannes Will,
- Theodoros Georgomanolis,
- Christina Vohlen,
- Rebecca Wilke,
- Baktybek Kojonazarov,
- Oleksiy Klymenko,
- Jasmine Mohr,
- Silke v. Koningsbruggen-Rietschel,
- Christopher J. Rhodes,
- Anna Ulrich,
- Dharmesh Hirani,
- Tim Nestler,
- Margarete Odenthal,
- Esther Mahabir,
- Sreenath Nayakanti,
- Swati Dabral,
- Thomas Wunderlich,
- James Priest,
- Werner Seeger,
- Jörg Dötsch,
- Soni S. Pullamsetti,
- Miguel A. Alejandre Alcazar
Affiliations
- Jaco Selle
- Faculty of Medicine and University Hospital Cologne, Translational Experimental Pediatrics–Experimental Pulmonology, Department of Pediatric and Adolescent Medicine, University of Cologne
- Katharina Dinger
- Faculty of Medicine and University Hospital Cologne, Translational Experimental Pediatrics–Experimental Pulmonology, Department of Pediatric and Adolescent Medicine, University of Cologne
- Vanessa Jentgen
- Faculty of Medicine and University Hospital Cologne, Translational Experimental Pediatrics–Experimental Pulmonology, Department of Pediatric and Adolescent Medicine, University of Cologne
- Daniela Zanetti
- Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine
- Johannes Will
- Faculty of Medicine and University Hospital Cologne, Translational Experimental Pediatrics–Experimental Pulmonology, Department of Pediatric and Adolescent Medicine, University of Cologne
- Theodoros Georgomanolis
- Faculty of Medicine and University Hospital Cologne, Cologne Center for Genomics (CCG), University of Cologne
- Christina Vohlen
- Faculty of Medicine and University Hospital Cologne, Translational Experimental Pediatrics–Experimental Pulmonology, Department of Pediatric and Adolescent Medicine, University of Cologne
- Rebecca Wilke
- Faculty of Medicine and University Hospital Cologne, Translational Experimental Pediatrics–Experimental Pulmonology, Department of Pediatric and Adolescent Medicine, University of Cologne
- Baktybek Kojonazarov
- Institute for Lung Health (ILH), University of Giessen and Marburg Lung Centre (UGMLC), Member of the German Centre for Lung Research (DZL)
- Oleksiy Klymenko
- Institute for Lung Health (ILH), University of Giessen and Marburg Lung Centre (UGMLC), Member of the German Centre for Lung Research (DZL)
- Jasmine Mohr
- Faculty of Medicine and University Hospital Cologne, Translational Experimental Pediatrics–Experimental Pulmonology, Department of Pediatric and Adolescent Medicine, University of Cologne
- Silke v. Koningsbruggen-Rietschel
- Faculty of Medicine and University Hospital Cologne, Pediatric Pulmonology, Department of Pediatric and Adolescent Medicine, University of Cologne
- Christopher J. Rhodes
- National Heart and Lung Institute, Hammersmith Campus, Imperial College London
- Anna Ulrich
- National Heart and Lung Institute, Hammersmith Campus, Imperial College London
- Dharmesh Hirani
- Faculty of Medicine and University Hospital Cologne, Translational Experimental Pediatrics–Experimental Pulmonology, Department of Pediatric and Adolescent Medicine, University of Cologne
- Tim Nestler
- Faculty of Medicine and University Hospital Cologne, Institute of Pathology, University of Cologne
- Margarete Odenthal
- Faculty of Medicine and University Hospital Cologne, Center for Molecular Medicine Cologne (CMMC), University of Cologne
- Esther Mahabir
- Faculty of Medicine and University Hospital Cologne, Comparative Medicine, Center for Molecular Medicine Cologne (CMMC), University of Cologne
- Sreenath Nayakanti
- Department of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL)
- Swati Dabral
- Department of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL)
- Thomas Wunderlich
- Faculty of Medicine and University Hospital Cologne, Center for Molecular Medicine Cologne (CMMC), University of Cologne
- James Priest
- Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine
- Werner Seeger
- Institute for Lung Health (ILH), University of Giessen and Marburg Lung Centre (UGMLC), Member of the German Centre for Lung Research (DZL)
- Jörg Dötsch
- Faculty of Medicine and University Hospital Cologne, Department of Pediatric and Adolescent Medicine, University of Cologne
- Soni S. Pullamsetti
- Institute for Lung Health (ILH), University of Giessen and Marburg Lung Centre (UGMLC), Member of the German Centre for Lung Research (DZL)
- Miguel A. Alejandre Alcazar
- Faculty of Medicine and University Hospital Cologne, Translational Experimental Pediatrics–Experimental Pulmonology, Department of Pediatric and Adolescent Medicine, University of Cologne
- DOI
- https://doi.org/10.1038/s41467-022-31655-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 21
Abstract
This study shows that maternal and perinatal obesity cause bronchial and vascular smooth muscle cell proliferation through an IL-6-FoxO1 axis, and favor thereby the emergence of bronchial obstruction and pulmonary hypertension later in life.
