Progress on the role and mechanism of ribosome assembly regulator PNO1 in tumor

Abstract

PNO1 (Dim2 or Rrp2 or YOR145), a highly conserved regulator of ribosome assembly from yeast to mammals, is involved in forming the 90S pre-ribosome and plays an essential role in the late stage of 40S small subunit maturation. Recent studies have found that PNO1 is involved in the progression of a variety of tumors and is highly expressed in colorectal, lung, esophageal, glioma, and breast cancer and is associated with poor prognosis. In tumors, PNO1 mainly promotes cell proliferation, invasion, and autophagy and inhibits apoptosis by regulating the P53 pathway, FAK/AKT pathway, Notch signaling pathway, and MAPK signaling pathway. The high expression of PNO1 in various tumors may be reduced by the regulation of early B cell factor 1 (EBF1), transcription factor MYC, miR-340-5p, and the drug celecoxib inhibiting tumor proliferation, invasion and migration, and autophagy, promoting apoptosis. This article reviews the structure and function of PNO1, related molecular pathways, and its regulatory role in tumor formation and discusses its possibility as a molecular target for tumor therapy.

Keywords

• pno1
• biological function
• signal pathway
• tumor
• cell proliferation
• invasion