Endoscopic calcium electroporation for colorectal cancer: a phase I study

Broholm Broholm; Vogelsang Vogelsang; Bulut Bulut; Stigaard Stigaard; Falk Falk; Frandsen Frandsen; Pedersen Pedersen; Perner Perner; Fiehn Fiehn; Mølholm Mølholm; Bzorek Bzorek; Rosen Rosen; Andersen Andersen; Pallisgaard Pallisgaard; Gögenur Gögenur; Gehl Gehl

doi:10.1055/a-2033-9831

Endoscopy International Open (May 2023)

Endoscopic calcium electroporation for colorectal cancer: a phase I study

Broholm Broholm,
Vogelsang Vogelsang,
Bulut Bulut,
Stigaard Stigaard,
Falk Falk,
Frandsen Frandsen,
Pedersen Pedersen,
Perner Perner,
Fiehn Fiehn,
Mølholm Mølholm,
Bzorek Bzorek,
Rosen Rosen,
Andersen Andersen,
Pallisgaard Pallisgaard,
Gögenur Gögenur,
Gehl Gehl

Affiliations

Broholm Broholm: Center for Surgical Science, Department of Surgery, Zealand University Hospital, Denmark
Vogelsang Vogelsang: Center for Surgical Science, Department of Surgery, Zealand University Hospital, Denmark
Bulut Bulut: Center for Surgical Science, Department of Surgery, Zealand University Hospital, Denmark
Stigaard Stigaard: Center for Surgical Science, Department of Surgery, Zealand University Hospital, Denmark
Falk Falk: Department of Oncology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark
Frandsen Frandsen: Center for Experimental Drug and Gene Electrotransfer (C*EDGE), Department of Clinical Oncology and Palliative Care, Zealand University Hospital, Roskilde, Denmark
Pedersen Pedersen: Department of Radiology, Zealand University Hospital, Denmark
Perner Perner: Department of Radiology, Zealand University Hospital, Denmark
Fiehn Fiehn: Center for Surgical Science, Department of Surgery, Zealand University Hospital, Denmark
Mølholm Mølholm: Visiopharm, Hoersholm, Denmark
Bzorek Bzorek: Department of Pathology, Zealand University Hospital, Denmark
Rosen Rosen: Center for Surgical Science, Department of Surgery, Zealand University Hospital, Denmark
Andersen Andersen: Department of Pathology, Zealand University Hospital, Denmark
Pallisgaard Pallisgaard: Department of Pathology, Zealand University Hospital, Denmark
Gögenur Gögenur: Center for Surgical Science, Department of Surgery, Zealand University Hospital, Denmark
Gehl Gehl: Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

DOI: https://doi.org/10.1055/a-2033-9831
Journal volume & issue: Vol. 11, no. 05
pp. E451 – E459

Abstract

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Background and study aims Colorectal cancer is one of the most common malignancies, with approximately 20 % of patients having metastatic disease. Local symptoms from the tumor remain a common issue and affect quality of life. Electroporation is a method to permeabilize cell membranes with high-voltage pulses, allowing increased passage of otherwise poorly permeating substances such as calcium. The aim of this study was to determine the safety of calcium electroporation for advanced colorectal cancer.

Published in Endoscopy International Open

ISSN: 2364-3722 (Print); 2196-9736 (Online)
Publisher: Georg Thieme Verlag KG
Country of publisher: Germany
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology
Website: https://doi.org/10.1055/s-00025476

About the journal