Psoriasis: Targets and Therapy (Jun 2024)
The Perspective of Cannabidiol in Psoriasis Therapy
Abstract
Ana Maria Alexandra Stanescu,1– 3 Gabriel Cristian Bejan,1 Mihaela Daniela Balta,1 Octavian Andronic,4 Cristian Toma,5,6 Stefan Busnatu7,8 1Department 5, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; 2Academy of Romanian Scientists (AOSR), Bucharest, Romania; 3Emil Palade” Center of Excellence for Young Researchers EP-CEYR The Academy of Romanian Scientists AOSR, Bucharest, Romania; 4Department 10, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; 5Department 3, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; 6“Prof.Dr. Theodor Burghele” Clinical Hospital, Bucharest, Romania; 7Department 4, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; 8Bagdasar Arseni Clin Emergency Hospital, Bucharest, RomaniaCorrespondence: Gabriel Cristian Bejan, “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, Sector 2, Bucharest, 020021, Romania, Email [email protected]: Psoriasis is a chronic skin condition that can significantly impact the quality of life of those affected. As an autoimmune disease, it can lead to itchy, painful, and scaly patches on the skin. Although various treatments, including topical creams, phototherapy, and systemic medications, are currently available, they may not always offer effective relief and can have side effects. Researchers have thus been exploring the potential benefits of non-psychoactive compounds such as CBD, found in Cannabis sativa plants, for treating psoriasis. CBD treatment may reduce inflammation, oxidative stress, itching, abnormal proliferation of keratinocytes, and may increase hydration. This review aims to provide an overview of the existing literature on the potential uses of CBD for psoriasis treatment.Keywords: psoriasis, cannabidiol, non-psychoactive compounds, treatment
